Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
about
EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics.Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice.Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding.LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.The physiology of mechanoelectrical transduction channels in hearing.Genetics of auditory mechano-electrical transduction.Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31.Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells.CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing lossThe 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearingCorrelation of actin crosslinker and capper expression levels with stereocilia growth phases.Gene expression profiles of the cochlea and vestibular endorgans: localization and function of genes causing deafness.Knowledge-based analysis of functional impacts of mutations in microRNA seed regions.Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner.Stereocilia morphogenesis and maintenance through regulation of actin stability.Global treadmilling coordinates actin turnover and controls the size of actin networks.In vivo physiological recording from the lateral line of juvenile zebrafishThe actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.Heterodimeric capping protein is required for stereocilia length and width regulation.
P2860
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P2860
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@ast
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@en
type
label
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@ast
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@en
prefLabel
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@ast
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@en
P2093
P2860
P50
P356
P1476
Progressive hearing loss and g ...... actin-binding protein Eps8L2.
@en
P2093
Bechara Kachar
Carole M Hackney
Christoph Franz
David N Furness
Guy P Richardson
Jennifer Olt
Richard J Goodyear
Sarath Vijayakumar
Sherri M Jones
Stuart L Johnson
P2860
P304
13898-13903
P356
10.1073/PNAS.1304644110
P407
P50
P577
2013-08-05T00:00:00Z