CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
about
CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells.Variants in CIB2 cause DFNB48 and not USH1J.A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles.Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.Mechanically Gated Ion Channels in Mammalian Hair Cells.Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea.Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteinsEvolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair CellsTransgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1
P2860
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P2860
CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
description
2017 nî lūn-bûn
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2017 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2017 թվականի հունիսին հրատարակված գիտական հոդված
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年學術文章
@yue
name
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@ast
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@en
type
label
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@ast
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@en
prefLabel
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@ast
CIB2 interacts with TMC1 and T ...... uction in auditory hair cells.
@en
P2093
P2860
P50
P1476
CIB2 interacts with TMC1 and T ...... duction in auditory hair cells
@en
P2093
Andrew Parker
Gregory I Frolenkov
Robert Fettiplace
Saima Riazuddin
Steve D M Brown
Yi-Quan Tang
Zubair M Ahmed
P2860
P2888
P356
10.1038/S41467-017-00061-1
P407
P577
2017-06-29T00:00:00Z
P6179
1090220851