The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. - Wikidata - wikimedia - TriplyDB

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

http://www.wikidata.org/entity/Q30577895

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Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling Innate immune pattern recognition: a cell biological perspective PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy Association of Lyn kinase with membrane rafts determines its negative influence on LPS-induced signaling Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation.A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages Emerging principles governing signal transduction by pattern-recognition receptors Uncoupling of pro- and anti-inflammatory properties of Staphylococcus aureus.PTEN-Foxo1 signaling triggers HMGB1-mediated innate immune responses in acute lung injury IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism.CD36 Differently Regulates Macrophage Responses to Smooth and Rough Lipopolysaccharide.Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway.STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.Disrupted PI3K p110δ Signaling Dysregulates Maternal Immune Cells and Increases Fetal Mortality In Mice.Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways.MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis.p110δ PI3 kinase pathway: emerging roles in cancer.Control of the innate immune response by the mevalonate pathway.Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling.Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages The immunobiology of toll-like receptor 4 agonists: from endotoxin tolerance to immunoadjuvants.PI3Kδ and primary immunodeficiencies.Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.Recognition of lipid A variants by the TLR4-MD-2 receptor complex.Mal, more than a bridge to MyD88.Immunopathogenesis of abdominal sepsis.Evolving Bacterial Envelopes and Plasticity of TLR2-Dependent Responses: Basic Research and Translational Opportunities Protein kinase networks that limit TLR signalling.Interferon regulatory factor 3 in adaptive immune responses.Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization.PI3K inhibitors in inflammation, autoimmunity and cancer.Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury.

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Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

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The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

http://www.wikidata.org/entity/Q30577895

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

@wuu

name

The p110δ isoform of the kinas ...... protects from endotoxic shock.

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The p110δ isoform of the kinas ...... protects from endotoxic shock.

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type

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The p110δ isoform of the kinas ...... protects from endotoxic shock.

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The p110δ isoform of the kinas ...... protects from endotoxic shock.

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prefLabel

The p110δ isoform of the kinas ...... protects from endotoxic shock.

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The p110δ isoform of the kinas ...... protects from endotoxic shock.

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Nature Immunology

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The p110δ isoform of the kinas ...... protects from endotoxic shock

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P2093

Alain Filloux

http://www.w3.org/2001/XMLSchema#string

Bart Vanhaesebroeck

http://www.w3.org/2001/XMLSchema#string

David Torres

http://www.w3.org/2001/XMLSchema#string

Gemma Nock

http://www.w3.org/2001/XMLSchema#string

Inma M Berenjeno

http://www.w3.org/2001/XMLSchema#string

Maria A Whitehead

http://www.w3.org/2001/XMLSchema#string

Rudi Beyaert

http://www.w3.org/2001/XMLSchema#string

Salma Taboubi

http://www.w3.org/2001/XMLSchema#string

Sandrine Delbauve

http://www.w3.org/2001/XMLSchema#string

Wayne P Pearce

http://www.w3.org/2001/XMLSchema#string

P2507

Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

P2860

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

Structure and physiological function of calpains

Toll-like receptor signalling

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs

Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion

mTOR signaling in growth control and disease

Innate immune recognition

The phosphoinositide 3-kinase pathway

P304

1045-1054

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scholarly article

P356

10.1038/NI.2426

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P433

11

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P478

13

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Abderrahman Hachani

Abderrahman Hachani

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2012-09-30T00:00:00Z

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231613080

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23023391

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Myeloid differentiation primary response gene 88

Toll-like receptor 4

Toll-like receptor

P932

4018573

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