eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. - Wikidata - wikimedia - TriplyDB

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.

http://www.wikidata.org/entity/Q30586619

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Pharmacological brake-release of mRNA translation enhances cognitive memory Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p β-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampus The roles of protein expression in synaptic plasticity and memory consolidation Remote control of gene function by local translation Genes and signaling pathways involved in memory enhancement in mutant mice Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory Proteolysis of proBDNF is a key regulator in the formation of memory eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory Regulation of translation initiation in eukaryotes: mechanisms and biological targets The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols Myosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous system Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth Translational control of auditory imprinting and structural plasticity by eIF2α.Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder.Transfer RNA and human disease From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.Aberrant plasticity of peripheral sensory axons in a painful neuropathy Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.A versatile method for cell-specific profiling of translated mRNAs in Drosophila.Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4.

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eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.

http://www.wikidata.org/entity/Q30586619

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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eIF2alpha phosphorylation bidi ...... ynaptic plasticity and memory.

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Claudio Cuello

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Delphine Gobert

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Elad Stern

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Jean-Claude Lacaille

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Jerry Pelletier

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Karim Nader

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Karine Gamache

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Kobi Rosenblum

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Kresimir Krnjević

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Mauro Costa-Mattioli

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P2860

A synaptic model of memory: long-term potentiation in the hippocampus

Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 {middle dot} GTP {middle dot} Met-tRNAiMet Ternary Complex Availability

Emotion circuits in the brain

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

Regulated translation initiation controls stress-induced gene expression in mammalian cells

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

The molecular biology of memory storage: a dialogue between genes and synapses

Place navigation impaired in rats with hippocampal lesions

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195-206

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10.1016/J.CELL.2007.01.050

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1

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129

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Nahum Sonenberg

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phosphorylation

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