Chemical inhibition of NAT10 corrects defects of laminopathic cells.
about
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsAnchoring a Leviathan: How the Nuclear Membrane Tethers the GenomeThe nuclear envelope: an intriguing focal point for neurogenetic diseaseIn silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells.Recent advances in understanding the role of lamins in health and diseaseDefining the orphan functions of lysine acetyltransferasesHuman NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1Chromatin Regulates Genome Targeting with Cisplatin.Chemoproteomic profiling of lysine acetyltransferases highlights an expanded landscape of catalytic acetylationAlterations in the nuclear proteome of HIV-1 infected T-cells.Unravelling the genomic targets of small molecules using high-throughput sequencing.RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombeThe Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus.High expression of N-acetyltransferase 10: a novel independent prognostic marker of worse outcome in patients with hepatocellular carcinoma.NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2.Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphaseNesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension.The Aging EpigenomeA High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.Nuclear lamina remodelling and its implications for human disease.Shaping of interphase chromosomes by the microtubule network.CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.The nuclear lamina in health and disease.Synthesis of marmycin A and investigation into its cellular activity.Next-generation phenotypic screening.Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.Causes and consequences of nuclear envelope alterations in tumour progression.Current insights into LMNA cardiomyopathies: Existing models and missing LINCsUp regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition.Light up Live Cell Nuclear Envelope in Real-Time Using a Two-Photon Absorption and AIE Chromophore.Nuclear envelopathies: a complex LINC between nuclear envelope and pathology.NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity.The structure of lamin filaments in somatic cells as revealed by cryo-electron tomography.Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) ExpressionPrelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradientA single acetylation of 18 S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae.Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
P2860
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P2860
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@ast
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@en
type
label
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@ast
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@en
prefLabel
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@ast
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@en
P2093
P2860
P356
P1433
P1476
Chemical inhibition of NAT10 corrects defects of laminopathic cells.
@en
P2093
Delphine Larrieu
Mukerrem Demir
Sébastien Britton
P2860
P304
P356
10.1126/SCIENCE.1252651
P407
P577
2014-05-01T00:00:00Z