Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
about
Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments.Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeChemical inhibition of NAT10 corrects defects of laminopathic cells.A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresIndividual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles.The nuclear envelope environment and its cancer connections.A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorderNuclear deformability constitutes a rate-limiting step during cell migration in 3-D environmentsThe Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.Reversal of laminopathies: the curious case of SUN1All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.Nuclear lamin functions and disease.Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease.Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.The contrasting roles of lamin B1 in cellular aging and human diseaseComparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation.Implications of multipotent mesenchymal stromal cell aging.Nuclear lamina remodelling and its implications for human disease.Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts.Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome.Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine.Biotinylation by antibody recognition-a method for proximity labeling.Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells.Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage.Non-farnesylated B-type lamin can tether chromatin inside the nucleus and its chromatin interaction requires the Ig-fold region.
P2860
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P2860
Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Protein farnesylation inhibito ...... a centrosome separation defect
@ast
Protein farnesylation inhibito ...... a centrosome separation defect
@en
type
label
Protein farnesylation inhibito ...... a centrosome separation defect
@ast
Protein farnesylation inhibito ...... a centrosome separation defect
@en
prefLabel
Protein farnesylation inhibito ...... a centrosome separation defect
@ast
Protein farnesylation inhibito ...... a centrosome separation defect
@en
P2093
P2860
P356
P1476
Protein farnesylation inhibito ...... a centrosome separation defect
@en
P2093
Elizabeth G Nabel
Jan Lammerding
Lana A Peckham
Loren G Fong
Michelle Olive
Stephen G Young
Valerie L R M Verstraeten
P2860
P304
P356
10.1073/PNAS.1019532108
P407
P577
2011-03-07T00:00:00Z