about
Evolution of the RAG1-RAG2 locus: both proteins came from the same transposonLong-Range Regulation of V(D)J RecombinationMolecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.Human RAG mutations: biochemistry and clinical implicationsMapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.Crystallographic phasing from weak anomalous signals.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesLate Onset Hypomorphic RAG2 Deficiency Presentation with Fatal Vaccine-Strain VZV Infection.DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus ImmunogenotypesRestoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination.Assembly and Expression of Shark Ig Genes.Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes.Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell developmentReal-time analysis of RAG complex activity in V(D)J recombinationH3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinaseNovel molecular mechanism for generating NK-cell fitness and memory.Characterization of T and B cell repertoire diversity in patients with RAG deficiencyTransposition of Mutator-like transposable elements (MULEs) resembles hAT and Transib elements and V(D)J recombination.The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures.New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure.HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination.Clinical, immunologic, and genetic characteristics of RAG mutations in 15 Chinese patients with SCID and Omenn syndrome.Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksBiochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position.Mechanisms and consequences of diversity-generating immune strategies.Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories.Mu transpososome activity-profiling yields hyperactive MuA variants for highly efficient genetic and genome engineering.DNA recombination defects in Kuwait: Clinical, immunologic and genetic profile.Hypomorphic Rag1 mutations alter the pre-immune repertoire at early stages of lymphoid development.Estimated disease incidence of RAG1/2 mutations: A case report and querying the Exome Aggregation Consortium.Cracking the DNA Code for V(D)J Recombination.Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposaseNew Contributions to Asarum Powder on Immunology Related Toxicity Effects in LungCation trafficking propels RNA hydrolysis
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Crystal structure of the V(D)J recombinase RAG1-RAG2
@ast
Crystal structure of the V(D)J recombinase RAG1-RAG2
@en
type
label
Crystal structure of the V(D)J recombinase RAG1-RAG2
@ast
Crystal structure of the V(D)J recombinase RAG1-RAG2
@en
prefLabel
Crystal structure of the V(D)J recombinase RAG1-RAG2
@ast
Crystal structure of the V(D)J recombinase RAG1-RAG2
@en
P2093
P2860
P921
P356
P1433
P1476
Crystal structure of the V(D)J recombinase RAG1-RAG2
@en
P2093
Martin Gellert
Mikalai Lapkouski
Min-Sung Kim
P2860
P2888
P304
P356
10.1038/NATURE14174
P407
P577
2015-02-18T00:00:00Z
P6179
1048726833