Pharmacological chaperone for α-crystallin partially restores transparency in cataract models
about
From structural biology to designing therapy for inborn errors of metabolismAggregate aufgelöstRecent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH.Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid HomeostasisLanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases.Systems biology of lens development: A paradigm for disease gene discovery in the eye.Small molecules, both dietary and endogenous, influence the onset of lens cataracts.Mutations and mechanisms in congenital and age-related cataracts.Small heat shock proteins in ageing and age-related diseases.Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract.Screening methods for identifying pharmacological chaperones.Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.Shaping proteostasis at the cellular, tissue, and organismal level.Pharmacological approaches to restoring lens transparency: Real world applications.Paradigm shifts, peregrinations and pixies in ophthalmology.Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract.Recent Advances in Understanding Werner Syndrome.BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future.Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro.Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.2016 EMBO Chemical Biology Conference.Ionizing radiation sensitivity of the ocular lens and its dose rate dependence.Effect of Green Tea Polyphenol Epigallocatechin-3-gallate on the Aggregation of αA(66-80) Peptide, a Major Fragment of αA-crystallin Involved in Cataract Development.Amyloid β-Sheet Secondary Structure Identified in UV-Induced Cataracts of Porcine Lenses using 2D IR Spectroscopy.Chaperone activity of human small heat shock protein-GST fusion proteins.Rosmarinic Acid Restores Complete Transparency of Sonicated Human Cataract Ex Vivo and Delays Cataract Formation In Vivo.Mapping interactions with the chaperone network reveals factors that protect against tau aggregationAmyloid assembly and disassemblyTerminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3
P2860
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P2860
Pharmacological chaperone for α-crystallin partially restores transparency in cataract models
description
2015 nî lūn-bûn
@nan
2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Pharmacological chaperone for ...... ransparency in cataract models
@ast
Pharmacological chaperone for ...... ransparency in cataract models
@en
type
label
Pharmacological chaperone for ...... ransparency in cataract models
@ast
Pharmacological chaperone for ...... ransparency in cataract models
@en
prefLabel
Pharmacological chaperone for ...... ransparency in cataract models
@ast
Pharmacological chaperone for ...... ransparency in cataract models
@en
P2093
P2860
P356
P1433
P1476
Pharmacological chaperone for ...... ransparency in cataract models
@en
P2093
Andrea D Thompson
Brittney N McGlasson
Bryan M Dunyak
Jason E Gestwicki
Joshua W Goldman
Kathryn A McMenimen
Leah N Makley
Ponni Rajagopal
Rachel E Klevit
Roger Sunahara
P2860
P304
P356
10.1126/SCIENCE.AAC9145
P407
P577
2015-11-01T00:00:00Z