Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.
about
Nutritional modulation of insulin resistanceLipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipidsCyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Regulation of the insulin gene by glucose and fatty acidsNutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.Glucolipotoxicity of the pancreatic beta cell.Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg DebatePancreatic steatosis: Is it related to either obesity or diabetes mellitus?Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Free fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways.Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition.Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.O-Linked β-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells.Nutrigenomics, beta-cell function and type 2 diabetesLow glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditionsGlucolipotoxicity: fuel excess and beta-cell dysfunction.Beta-cell failure as a complication of diabetes.Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance.High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15.Regulation of leptin secretion from white adipocytes by free fatty acids.15 Hz electroacupuncture at ST36 improves insulin sensitivity and reduces free fatty acid levels in rats with chronic dexamethasone-induced insulin resistance.
P2860
Q26824738-F605C6E7-5CCE-4122-83AD-3392127621ABQ28361455-767020D1-11DE-4FE7-83C2-447499A1957DQ28577842-96879F1C-554B-492F-BA27-14A73EDA6A86Q28609723-7E5B0F70-0567-463A-B5F4-89FCD21B3687Q30368908-C627B935-2538-4542-A6CB-29C0CC074CF0Q30418321-5C20CACC-E65A-4C62-ABC2-C75B719F32C7Q30994890-A5EA6FB9-15F7-43DE-9899-E2FAD33914EEQ33665283-A2132828-E1D5-48D0-97AE-EC8B72F29309Q33838645-1A881653-C7AC-44BC-B64C-AEA36F15F327Q34023530-4482A7AF-9035-4127-BA1C-2B49EFC02D4BQ34338020-04ECAA53-3B48-44C5-B30C-95C3349A202AQ34635587-C26ADC4B-63F4-429D-B3C3-27052F83B185Q35140269-B6CCA22D-9416-49C2-BD31-257D31788865Q35564064-7DBFF9AD-40B6-4138-A26F-495942F9BF5EQ35667288-D7484FF9-85DC-4F29-BBD3-5F91D33862A0Q36518241-0322FE3E-F594-4347-8FF3-3FE6806CC160Q36775874-62C57CA7-EFD7-4632-BCAD-B381A0CBFDD2Q36844402-1A50C7E6-EEB4-4788-9A7B-3996871829FCQ36861036-6B916668-DAD0-4780-9176-70B0C9C3065DQ37262812-0B4B605F-8FA6-429D-975D-E54C70CCD064Q37472776-B1A84350-148A-43FD-B054-97D0C91198EAQ40639986-4DFDCB48-81E8-431F-B4A3-A76A145EF1B2Q42440847-CE03B8CC-2E7F-48EA-B016-6CEDE570ABD5Q47590397-54B4D254-DCFE-4050-A494-F9AF4C6A54B4
P2860
Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@ast
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@en
type
label
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@ast
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@en
prefLabel
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@ast
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@en
P2093
P356
P1433
P1476
Glucose-induced preproinsulin ...... the free fatty acid palmitate.
@en
P2093
Charollais A
Constant I
Philippe J
Ritz-Laser B
P304
P356
10.1210/ENDO.140.9.6953
P407
P577
1999-09-01T00:00:00Z