Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
about
Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob miceInteraction between Glucose and Lipid Metabolism: More than Diabetic DyslipidemiaEndoplasmic reticulum stress and type 2 diabetesGuards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsProtein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensingPPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunctionCyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Regulation of the insulin gene by glucose and fatty acidsRole of ceramide in diabetes mellitus: evidence and mechanisms.12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice.Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.An islet in distress: β cell failure in type 2 diabetes.Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Glucolipotoxicity of the pancreatic beta cell.Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis.Adipose differentiation-related protein regulates lipids and insulin in pancreatic isletsGlucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance.Free fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways.Effects of free fatty acids on insulin secretion in obesity.Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cellsCharacterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathyDiabetes, lipids, and adipocyte secretagogues.A simple matter of life and death-the trials of postnatal Beta-cell mass regulationPerspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell deathDiscovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone
P2860
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P2860
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@ast
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@en
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@nl
type
label
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@ast
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@en
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@nl
prefLabel
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@ast
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@en
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@nl
P2093
P2860
P3181
P1433
P1476
Lipotoxicity of the pancreatic ...... atty acids into neutral lipids
@en
P2093
P2860
P304
P3181
P356
10.2337/DIABETES.50.2.315
P407
P577
2001-02-01T00:00:00Z