Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. - Wikidata - wikimedia - TriplyDB

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

http://www.wikidata.org/entity/Q34338020

about

Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.Regulation of the insulin gene by glucose and fatty acids Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.An islet in distress: β cell failure in type 2 diabetes.Glucolipotoxicity of the pancreatic beta cell.Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate Lipid receptors and islet function: therapeutic implications?Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.The transcription factor Myt3 acts as a pro-survival factor in β-cells MAFA controls genes implicated in insulin biosynthesis and secretion Free fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways.Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.The class I histone deacetylase inhibitor MS-275 prevents pancreatic beta cell death induced by palmitate.Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.Glucolipotoxicity in Pancreatic β-Cells.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids.Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress A simple matter of life and death-the trials of postnatal Beta-cell mass regulation Aldosterone induces clonal β-cell failure through glucocorticoid receptor.Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells.Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression.Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass.Bioactivity of a modified human Glucagon-like peptide-1.Nutrigenomics, beta-cell function and type 2 diabetes Update on the protective molecular pathways improving pancreatic beta-cell dysfunction Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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P2860

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

http://www.wikidata.org/entity/Q34338020

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

@ast

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

@en

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

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type

label

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

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Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

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Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

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prefLabel

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

@ast

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

@en

Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

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P1433

Journal of Biological Chemistry

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Palmitate inhibits insulin gen ...... ated rat islets of Langerhans.

@en

P2093

Derek K Hagman

http://www.w3.org/2001/XMLSchema#string

Lori B Hays

http://www.w3.org/2001/XMLSchema#string

Susan D Parazzoli

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Vincent Poitout

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P2860

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

Regulation of insulin gene transcription

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

Conserved transcriptional regulatory domains of the pdx-1 gene

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32413-32418

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scholarly article

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10.1074/JBC.M506000200

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P433

37

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280

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7798540

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15944145

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1361267

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