Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
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Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?Aggrecanases and cartilage matrix degradationRegional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.Cartilage to bone transitions in health and diseaseExpression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degenerationCatabolism of aggrecan, decorin and biglycan in tendon.Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro studyPatients with rheumatoid arthritis have an altered circulatory aggrecan profile.In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments.Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes.The roles of catabolic factors in the development of osteoarthritis.MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritisRat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degenerationSelective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses.Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.Oxygen tension modulates the effects of TNFα in compressed chondrocytesCartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityEffects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts.Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple MechanismsAnalysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing iThe mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.Perineuronal net degradation in epilepsy.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.Proinflammatory cytokine activities, matrix metalloproteinase-3 activity, and sulfated glycosaminoglycan content in synovial fluid of dogs with naturally acquired cranial cruciate ligament rupture.In vitro and in vivo evaluation of doxycycline-chondroitin sulfate/PCLmicrospheres for intraarticular treatment of osteoarthritis.Generation of anti-complement "prodrugs": cleavable reagents for specific delivery of complement regulators to disease sites.Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1β-induced expression of matrix metalloproteinase via activation of NF-κB in human chondrocytes.Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics.Effects of n-3 fatty acids on cartilage metabolism
P2860
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P2860
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@ast
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@en
type
label
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@ast
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@en
prefLabel
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@ast
Aggrecanase versus matrix meta ...... r domain of aggrecan in vitro.
@en
P2093
P2860
P50
P1433
P1476
Aggrecanase versus matrix meta ...... ar domain of aggrecan in vitro
@en
P2093
P2860
P356
10.1042/0264-6021:3440061
10.1042/BJ3440061
P407
P478
P577
1999-11-01T00:00:00Z