Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i
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ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndromeAggrecanases and cartilage matrix degradationADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritisThe ADAMTS(L) family and human genetic disordersCharacterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular CartilageMatrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activityTenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.The proteoglycan metabolism of articular cartilage in joint-scale culture.Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfateAdult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilageAggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications.Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate.ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and ChondrocytesExtracellular processing of the cartilage proteoglycan aggregate and its effect on CD44-mediated internalization of hyaluronanAnalysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography.ADAMTS-18: a metalloproteinase with multiple functionsProteases involved in cartilage matrix degradation in osteoarthritis.The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis.Articular chondrocytes derived from distinct tissue zones differentially respond to in vitro oscillatory tensile loading.Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.The role of aggrecan in normal and osteoarthritic cartilage.Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersAge-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study.The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases.Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
P2860
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P2860
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Analysis of aggrecan in human ...... ed for C-terminal processing i
@en
Analysis of aggrecan in human ...... uid indicates that aggrecanase
@nl
type
label
Analysis of aggrecan in human ...... ed for C-terminal processing i
@en
Analysis of aggrecan in human ...... uid indicates that aggrecanase
@nl
prefLabel
Analysis of aggrecan in human ...... ed for C-terminal processing i
@en
Analysis of aggrecan in human ...... uid indicates that aggrecanase
@nl
P2860
P1433
P1476
Analysis of aggrecan in human ...... ed for C-terminal processing i
@en
P2093
Verscharen C
P2860
P304
P356
10.1042/0264-6021:3580615
P407
P577
2001-09-01T00:00:00Z