The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domainMatrix metalloproteinases cleave at two distinct sites on human cartilage link proteinNeutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecanAge-related changes in the content of the C-terminal region of aggrecan in human articular cartilageAggrecanases and cartilage matrix degradationThe fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribsEgr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signallingThe effect of neonatal gene therapy on skeletal manifestations in mucopolysaccharidosis VII dogs after a decade.Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Articular cartilage and osteoarthrosis. The role of molecular markers to monitor breakdown, repair and disease.In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritisMMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeuticsMyocardial matrix metalloproteinase-2: inside out and upside down.Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis.Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion.Proteases involved in cartilage matrix degradation in osteoarthritis.Somatic antigens of tropical liver flukes ameliorate collagen-induced arthritis in wistar ratsBlocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairMatrix metalloproteinase 9 modulates collagen matrices and wound repairRecent findings on the role of gelatinases (matrix metalloproteinase-2 and -9) in osteoarthritisCrocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.Characterization of recombinant human cathepsin B expressed at high levels in baculovirus.The role of aggrecan in normal and osteoarthritic cartilage.Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption.Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment.Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption.Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity.Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityVariations in aggrecan structure modulate its susceptibility to aggrecanases.Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecanExpression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage.Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis
P2860
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P2860
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@ast
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@en
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@nl
type
label
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@ast
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@en
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@nl
prefLabel
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@ast
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@en
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@nl
P2093
P1476
The interglobular domain of ca ...... gelatinases, and cathepsin B.
@en
P2093
P304
19470-19474
P407
P577
1992-09-01T00:00:00Z