The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
about
Regulation of lysosomal ion homeostasis by channels and transportersTwo-pore channels at the intersection of endolysosomal membrane trafficExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thalianaStructure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thalianaLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityNaringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.Lysosomal physiology.Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.Function and dysfunction of two-pore channels.Two-Pore Channels: Lessons from Mutant Mouse ModelsTwo-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasisOrganellar channels and transporters.Soluble adenylyl cyclase is essential for proper lysosomal acidificationTwo-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.Ion transport in pigmentation.Ca2+ signalling in plant immune response: from pattern recognition receptors to Ca2+ decoding mechanisms.Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H+ exchange activity.Poring over two-pore channel pore mutants.Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.On the structure and mechanism of two-pore channels.Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines.Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.A melanosomal two-pore sodium channel regulates pigmentation.The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix.A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability.Hypoxia Sensing in Plants: On a Quest for Ion Channels as Putative Oxygen Sensors.NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin.Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity.Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain.Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.Two-pore channels and disease.
P2860
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P2860
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@ast
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@en
type
label
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@ast
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@en
prefLabel
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@ast
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
@en
P2860
P356
P1476
The voltage-gated sodium channel TPC1 confers endolysosomal excitability
@en
P2093
Biruk Bekele
Dejian Ren
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1522
P50
P577
2014-04-28T00:00:00Z