Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
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Discovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics.Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.The PIK3CA gene as a mutated target for cancer therapy.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Akt2 phosphorylates ezrin to trigger NHE3 translocation and activationAn allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo.Discovery of Akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents.Pharmacogenetic candidate genes for melanoma.Phosphorylation of Beet black scorch virus coat protein by PKA is required for assembly and stability of virus particles.The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) DomainRecent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain.Inhibition of Akt pathways in the treatment of prostate cancer.Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1Recent development of anticancer therapeutics targeting Akt.Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors.Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells.Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domainRationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.The pp60c-Src inhibitor PP1 is non-competitive against ATP.Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways.Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.Cyclic-AMP-dependent protein kinase (PKA) activity assay based on FRET between cationic conjugated polymer and chromophore-labeled peptide.Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity.Phosphorylation-Dependent Inhibition of Akt1
P2860
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P2860
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
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2002年學術文章
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name
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@ast
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@en
type
label
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@ast
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@en
prefLabel
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@ast
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@en
P2093
P356
P1433
P1476
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
@en
P2093
Alexander Levitzki
Gary Gellerman
Hadas Reuveni
Ilana Cohen
Moran Benhar
Nurit Livnah
Osnat Ohne
Shoshana Klein
Tamar Geiger
P304
10304-10314
P356
10.1021/BI0202530
P407
P577
2002-08-01T00:00:00Z