Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.
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Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia.Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesteroneThe PIK3CA gene as a mutated target for cancer therapy.Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex.In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membraneIdentification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element.A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1.The TCL1 family of oncoproteins: co-activators of transformation.Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis.Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia.Inhibition of Akt pathways in the treatment of prostate cancer.Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions.Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae.Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides.Recent development of anticancer therapeutics targeting Akt.T-cell receptor signaling in peripheral T-cell lymphoma - a review of patterns of alterations in a central growth regulatory pathway.Penetrating the cell membrane, thermal targeting and novel anticancer drugs: the development of thermally targeted, elastin-like polypeptide cancer therapeutics.AzaGly-Appended Peptidomimetics Structurally Related to PTR6154 as Potential PKB/Akt Inhibitors.Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway.Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice.Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival.The role of insulin-like growth factors signaling in merlin-deficient human schwannomas.Probing Akt-inhibitor interaction by chemical cross-linking and mass spectrometry.TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.LLO-mediated Cell Resealing System for Analyzing Intracellular Activity of Membrane-impermeable Biopharmaceuticals of Mid-sized Molecular Weight.Identification of a functional phosphatidylinositol 3,4,5-trisphosphate binding site in the epithelial Na+ channel.T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways
P2860
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P2860
Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Inhibition of Akt kinase activ ...... nd of the proto-oncogene TCL1.
@en
type
label
Inhibition of Akt kinase activ ...... nd of the proto-oncogene TCL1.
@en
prefLabel
Inhibition of Akt kinase activ ...... nd of the proto-oncogene TCL1.
@en
P2093
P2860
P356
P1476
Inhibition of Akt kinase activ ...... and of the proto-oncogene TCL1
@en
P2093
Christian Roumestand
Makoto Hiromura
Masayuki Noguchi
Takeshi Shibata
Toshiyuki Obata
P2860
P304
53407-53418
P356
10.1074/JBC.M403775200
P407
P577
2004-09-30T00:00:00Z