Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
about
The metabolic serine hydrolases and their functions in mammalian physiology and disease.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Distinct Entry Mechanisms for Nonenveloped and Quasi-Enveloped Hepatitis E VirusesPhysiological difference in autophagic flux in macrophages from 2 mouse strains regulates cholesterol ester metabolismAutophagosomes contribute to intracellular lipid distribution in enterocytes.Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.Thiadiazole-a promising structure in medicinal chemistry.Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency.Lysosomal acid lipase deficiency: a form of non-obese fatty liver disease (NOFLD).Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.Niemann-Pick disease type C: analysis of 7 patients.Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
P2860
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P2860
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@en
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@nl
type
label
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@en
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@nl
prefLabel
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@en
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@nl
P2093
P2860
P356
P1476
Thiadiazole carbamates: potent ...... k type C disease therapeutics.
@en
P2093
Anton I Rosenbaum
Casey C Cosner
Christopher J Mariani
Frederick R Maxfield
Olaf Wiest
Paul Helquist
P2860
P304
P356
10.1021/JM100499S
P407
P577
2010-07-01T00:00:00Z