The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.
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Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry.The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistanceStructure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.Substrate recognition and modification by the nosiheptide resistance methyltransferaseCrystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometrySequence and structural evolution of the KsgA/Dim1 methyltransferase familyRecombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics.Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferasesMacrolide resistance conferred by base substitutions in 23S rRNA.Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria.Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.Triggers and cues that activate antibiotic production by actinomycetes.The expression of antibiotic resistance genes in antibiotic-producing bacteria.Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA.Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility.
P2860
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P2860
The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@ast
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@en
type
label
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@ast
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@en
prefLabel
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@ast
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA.
@en
P2860
P1476
The tylosin resistance gene tl ...... that targets G748 in 23S rRNA
@en
P2093
P2860
P304
P356
10.1046/J.1365-2958.2000.02046.X
P407
P577
2000-08-01T00:00:00Z