Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.
about
Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin floraStructure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsMechanism of activation of methyltransferases involved in translation by the Trm112 'hub' proteinThe bacterial ribosome as a target for antibioticsCrystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometryMinimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida.23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocidaGlycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins.Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors.Antibiotics and the ribosome.Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitorsBiofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and MelanogenesisStructures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.Use of RNA in drug design.Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolidesTwo-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification.Toward the rational design of macrolide antibiotics to combat resistance.Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin.Resistance to Macrolide Antibiotics in Public Health Pathogens.Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA.Binding site of the bridged macrolides in the Escherichia coli ribosome.Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.Parametrization of macrolide antibiotics using the force field toolkit.Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606.
P2860
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P2860
Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@ast
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@en
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@nl
type
label
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@ast
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@en
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@nl
prefLabel
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@ast
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@en
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@nl
P2860
P356
P1476
Resistance to the macrolide an ...... 8 and A2058 acting in synergy.
@en
P2093
Mingfu Liu
P2860
P304
14658-14663
P356
10.1073/PNAS.232580599
P407
P577
2002-11-04T00:00:00Z