A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.
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Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesisStructural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteriaStructure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII.Structural Insight into the Antibiotic Action of Telithromycin against Resistant MutantsThe structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsStructures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionThe bacterial ribosome as a target for antibioticsThe tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometryKetolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm.A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida.ABT-773: a new ketolide antibiotic.23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocidaIn vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus speciesSuppression of nonsense mutations induced by expression of an RNA complementary to a conserved segment of 23S rRNA.Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNADiversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.Macrolide resistance conferred by base substitutions in 23S rRNA.Ribosomal mutations in Streptococcus pneumoniae clinical isolatesMethylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria.Designer drugs for discerning bugs.Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.Telithromycin: an oral ketolide for respiratory infections.Ketolides in the treatment of respiratory infections.Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance.Novel antibacterial agents for the treatment of serious Gram-positive infections.23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Application of molecular genetic methods in macrolide, lincosamide and streptogramin resistance diagnostics and in detection of drug-resistant Mycobacterium tuberculosis.New research in macrolides and ketolides since 1997.The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance.Species-specific antibiotic-ribosome interactions: implications for drug development.Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.Antibiotics and the ribosome.Induction of erm(C) expression by noninducing antibiotics.Telithromycin in the treatment of acute bacterial sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumoniaMacrolide myths.Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.
P2860
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P2860
A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
A ketolide resistance mutation ...... e peptidyl transferase centre.
@ast
A ketolide resistance mutation ...... e peptidyl transferase centre.
@en
type
label
A ketolide resistance mutation ...... e peptidyl transferase centre.
@ast
A ketolide resistance mutation ...... e peptidyl transferase centre.
@en
prefLabel
A ketolide resistance mutation ...... e peptidyl transferase centre.
@ast
A ketolide resistance mutation ...... e peptidyl transferase centre.
@en
P2093
P2860
P1476
A ketolide resistance mutation ...... e peptidyl transferase centre.
@en
P2093
P2860
P304
P356
10.1046/J.1365-2958.1999.01203.X
P407
P577
1999-01-01T00:00:00Z