Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Item
http://www.wikidata.org/entity/Q31057900
Molecular Targets in Alzheimer's Disease: From Pathogenesis to TherapeuticsAlzheimer's Disease: Mechanism and Approach to Cell TherapyStem Cell Therapy: A Prospective Treatment for Alzheimer's DiseaseThe amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy.Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaquesOligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.Presenilin E318G variant and Alzheimer's disease risk: the Cache County study.Upregulated function of mitochondria-associated ER membranes in Alzheimer diseaseEffect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FADAnalysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.The genes associated with early-onset Alzheimer's disease.Efficient production of a mature and functional gamma secretase protease
P2860

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Item
http://www.wikidata.org/entity/Q31057900
description
2012 nî lūn-bûn
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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
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2012年論文
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2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@ast
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@en
type
label
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@ast
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@en
prefLabel
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@ast
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Alzheimer's disease-linked mut ...... urified γ-secretase complexes.
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0035133
P407
P433
P478
P50
P577
P5875
P698
P921
P932