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Purification and characterization of the human gamma-secretase complexElectron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae.The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Gene expression profiling in cells with enhanced gamma-secretase activity.Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells.Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases.The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptidesThe role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Substrate-targeting gamma-secretase modulatorsInhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescenceShedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.Production of active glycosylation-deficient γ-secretase complex for crystallization studies.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.A compressible scaffold for minimally invasive delivery of large intact neuronal networks.Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.Detection of Alzheimer's disease amyloid-beta plaque deposition by deep brain impedance profiling.Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila.Accurate resistivity mouse brain mapping using microelectrode arrays.Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.The glycosylphosphatidylinositol (GPI) signal sequence of human placental alkaline phosphatase is not recognized by human Gpi8p in the context of the yeast GPI anchoring machinery.The lipidome associated with the γ-secretase complex is required for its integrity and activity.Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy.Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase.Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Patrick C Fraering
@ast
Patrick C Fraering
@en
Patrick C Fraering
@es
Patrick C Fraering
@nl
Patrick C Fraering
@sl
type
label
Patrick C Fraering
@ast
Patrick C Fraering
@en
Patrick C Fraering
@es
Patrick C Fraering
@nl
Patrick C Fraering
@sl
prefLabel
Patrick C Fraering
@ast
Patrick C Fraering
@en
Patrick C Fraering
@es
Patrick C Fraering
@nl
Patrick C Fraering
@sl
P106
P21
P31
P496
0000-0002-5841-5327
P569
2000-01-01T00:00:00Z