DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. - Wikidata - wikimedia - TriplyDB

DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.

DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.

http://www.wikidata.org/entity/Q31079394

about

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function ATR-mediated regulation of nuclear and cellular plasticity A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair.Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.Functional characterization of a cancer causing mutation in human replication protein A Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Elevated level of human RPA interacting protein α (hRIPα) in cervical tumor cells is involved in cell proliferation through regulating RPA transport.A relationship between replication protein A and occurrence and prognosis of esophageal carcinoma.Meiotic recombination and spatial proximity in the etiology of the recurrent t(11;22)Viral interference with DNA repair by targeting of the single-stranded DNA binding protein RPA.Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma.The fork and the kinase: a DNA replication tale from a CHK1 perspective.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells Cdc45 is limiting for replication initiation in humans The DNA-polymerase-X family: controllers of DNA quality?Stress-induced corneal epithelial apoptosis mediated by K+ channel activation Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.

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P2860

DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.

http://www.wikidata.org/entity/Q31079394

description

2004 nî lūn-bûn

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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

DNA replication defects, spont ...... ion protein A-deficient cells.

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DNA replication defects, spont ...... ion protein A-deficient cells.

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DNA replication defects, spont ...... ion protein A-deficient cells.

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DNA replication defects, spont ...... ion protein A-deficient cells.

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DNA replication defects, spont ...... ion protein A-deficient cells.

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Journal of Biological Chemistry

P1476

DNA replication defects, spont ...... ion protein A-deficient cells.

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P2093

Gerald E Dodson

http://www.w3.org/2001/XMLSchema#string

Randal S Tibbetts

http://www.w3.org/2001/XMLSchema#string

Yuling Shi

http://www.w3.org/2001/XMLSchema#string

P2860

Replication Protein A (RPA): The Eukaryotic SSB

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

Megabase chromatin domains involved in DNA double-strand breaks in vivo

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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34010-34014

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scholarly article

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10.1074/JBC.C400242200

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32

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279

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2004-06-14T00:00:00Z

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15197179

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P921