DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
about
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeresCellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpointsA naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progressionATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationPreferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damageInvolvement of nucleotide excision and mismatch repair mechanisms in double strand break repairTipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint functionATR-mediated regulation of nuclear and cellular plasticityA DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cellsNovel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responsesRPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair.Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.Functional characterization of a cancer causing mutation in human replication protein AReplication stress induces micronuclei comprising of aggregated DNA double-strand breaksRole of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksInfluence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Elevated level of human RPA interacting protein α (hRIPα) in cervical tumor cells is involved in cell proliferation through regulating RPA transport.A relationship between replication protein A and occurrence and prognosis of esophageal carcinoma.Meiotic recombination and spatial proximity in the etiology of the recurrent t(11;22)Viral interference with DNA repair by targeting of the single-stranded DNA binding protein RPA.Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma.The fork and the kinase: a DNA replication tale from a CHK1 perspective.RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human CellsCdc45 is limiting for replication initiation in humansThe DNA-polymerase-X family: controllers of DNA quality?Stress-induced corneal epithelial apoptosis mediated by K+ channel activationReplication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.
P2860
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P2860
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
DNA replication defects, spont ...... ion protein A-deficient cells.
@ast
DNA replication defects, spont ...... ion protein A-deficient cells.
@en
type
label
DNA replication defects, spont ...... ion protein A-deficient cells.
@ast
DNA replication defects, spont ...... ion protein A-deficient cells.
@en
prefLabel
DNA replication defects, spont ...... ion protein A-deficient cells.
@ast
DNA replication defects, spont ...... ion protein A-deficient cells.
@en
P2093
P2860
P356
P1476
DNA replication defects, spont ...... ion protein A-deficient cells.
@en
P2093
Gerald E Dodson
Randal S Tibbetts
Yuling Shi
P2860
P304
34010-34014
P356
10.1074/JBC.C400242200
P407
P577
2004-06-14T00:00:00Z