Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Akt and autophagy cooperate to promote survival of drug-resistant gliomaRegulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Synthetic applications of fluorous solid-phase extraction (F-SPE)Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancerTen things you should know about protein kinases: IUPHAR Review 14Drugs for allosteric sites on receptorsDysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null miceDiscovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionAn ATP-site on-off switch that restricts phosphatase accessibility of AktAkt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibitionInsulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasisSynthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosisModulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxiaComputational insights into the inhibitory mechanism of human AKT1 by an orally active inhibitor, MK-2206Molecular cues on obesity signals, tumor markers and endometrial cancer.Pseudokinases: update on their functions and evaluation as new drug targets.Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Automation of fluorous solid-phase extraction for parallel synthesis.Microwave-Enhanced High-Speed Fluorous Synthesis.Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signalingThe PIK3CA gene as a mutated target for cancer therapy.AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyveA small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effectsA chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.Chiral kinase inhibitors.Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor functionNovel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Small-molecule inhibitors of the PI3K signaling networkInhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding.
P2860
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P2860
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@ast
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@en
type
label
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@ast
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@en
prefLabel
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@ast
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@en
P2093
P1476
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
@en
P2093
Deborah Defeo-Jones
George D Hartman
Hans E Huber
Joel R Huff
Mark E Duggan
Raymond E Jones
Ronald G Robinson
Stanley F Barnett
William H Leister
Zhijian Zhao
P304
P356
10.1016/J.BMCL.2004.11.011
P407
P577
2005-02-01T00:00:00Z