Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
about
A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsClass II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptorsPhosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationThe SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytesHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorThe 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase SypTwo signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorSpecific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activationIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinaseSrc phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaThe SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signallingSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeHigh-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domainsSignal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signalingIdentification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimeraThe SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsPhosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMPDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsChronic immune activation and inflammation as the cause of malignancyTyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinaseFab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasisThe protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signalingTime-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modulesPhosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activityRegulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of phosphatidylinositol 3-kinase activityThe p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complexThe catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexesPI3K/PTEN signaling in angiogenesis and tumorigenesisAST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivoA novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingShort-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesisRequirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesisA Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance.Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line.Oncogenes, Protein Tyrosine Kinases, and Signal Transduction.
P2860
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P2860
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Interaction of phosphatidylino ...... erived growth factor receptors
@ast
Interaction of phosphatidylino ...... erived growth factor receptors
@en
type
label
Interaction of phosphatidylino ...... erived growth factor receptors
@ast
Interaction of phosphatidylino ...... erived growth factor receptors
@en
prefLabel
Interaction of phosphatidylino ...... erived growth factor receptors
@ast
Interaction of phosphatidylino ...... erived growth factor receptors
@en
P2093
P2860
P356
P1476
Interaction of phosphatidylino ...... erived growth factor receptors
@en
P2093
P2860
P304
P356
10.1128/MCB.12.3.981
P407
P577
1992-03-01T00:00:00Z