about
Early invasion of brain parenchyma by African trypanosomesPhysical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repairCrystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma bruceiMining a cathepsin inhibitor library for new antiparasitic drug leadsExamination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertiiDNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.Structure and function of mammalian DNA ligases.Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties.A parasite cysteine protease is key to host protein degradation and iron acquisition.Drugs targeting parasite lysosomes.A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infectionA cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues.An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei.Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression.Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Zachary B. Mackey
@ast
Zachary B. Mackey
@en
Zachary B. Mackey
@es
Zachary B. Mackey
@sl
type
label
Zachary B. Mackey
@ast
Zachary B. Mackey
@en
Zachary B. Mackey
@es
Zachary B. Mackey
@sl
prefLabel
Zachary B. Mackey
@ast
Zachary B. Mackey
@en
Zachary B. Mackey
@es
Zachary B. Mackey
@sl
P106
P108
P1153
6603290428
P21
P31
P496
0000-0002-4533-0973