Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.

Item
http://www.wikidata.org/entity/Q31440490
Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3Closed headpiece of integrin  IIb 3 and its complex with an  IIb 3-specific antagonist that does not induce openingAdvances in the development of thrombin inhibitorsSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamMolecular dynamics simulations of conformational behavior of linear RGD peptidomimetics and cyclic prodrugs in aqueous and octane solutions.A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3.The diverse roles of integrins and their ligands in angiogenesis.Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeuticsIntact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopyDiscovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction.RP-HPLC Method Development and Validation for Determination of Eptifibatide Acetate in Bulk Drug Substance and Pharmaceutical Dosage Forms.The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.Syntheses of cyclic prodrugs of RGD peptidomimetics with various macrocyclic ring sizes: evaluation of physicochemical, transport and antithrombic properties.Conformationally tailored N-[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]proline templates as molecular tools for the design of peptidomimetics. Design and synthesis of fibrinogen receptor antagonists.A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits.
P2860

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.

Item
http://www.wikidata.org/entity/Q31440490
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@ast
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@en
type
label
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@ast
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@en
prefLabel
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@ast
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
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P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Platelet glycoprotein IIb-IIIa ...... al oral antithrombotic agents.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698