Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
about
Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discoveryBH3 mimetics to improve cancer therapy; mechanisms and examplesTargeting Cell Survival Proteins for Cancer Cell DeathTargeting the Bcl-2 family for cancer therapyTargeting the apoptosis pathway in hematologic malignanciesBcl-XL mutations suppress cellular sensitivity to antimycin AConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsUbiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiationMono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functionsDiscovery of potent broad spectrum antivirals derived from marine actinobacteriaAnticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approachesSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamMARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival.Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property.Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalThe mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.Qualitative determination of superoxide release at both sides of the mitochondrial inner membrane by capillary electrophoretic analysis of the oxidation products of triphenylphosphonium hydroethidine.Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium.Chemical cytometry quantitates superoxide levels in the mitochondrial matrix of single myoblasts.Emerging Bcl-2 inhibitors for the treatment of cancer.Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction.The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solutionCombining 2-deoxy-D-glucose with electron transport chain blockers: a double-edged sword.Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblastsBH3-only proteins in apoptosis and beyond: an overview.Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.Control of Bcl-2 expression by reactive oxygen speciesRare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-RasReconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax proteinRole of Bcl-2 family of proteins in malignancy.Killing of sarcoma cells by proapoptotic Bcl-X(S): role of the BH3 domain and regulation by Bcl-X(L).Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivoNMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.Mitochondria as a target for inducing death of malignant hematopoietic cells.
P2860
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P2860
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@ast
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@en
type
label
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@ast
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@en
prefLabel
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@ast
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@en
P2093
P356
P1433
P1476
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
@en
P2093
Hockenbery DM
Zimmerberg J
P2888
P304
P356
10.1038/35055095
P577
2001-02-01T00:00:00Z
P6179
1037919537