(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo - Wikidata - wikimedia - TriplyDB

(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

http://www.wikidata.org/entity/Q35052194

about

BH3 mimetics to improve cancer therapy; mechanisms and examples SIRT3 and cancer: tumor promoter or suppressor?Neoplasia: Where We Have Been and Where We Are Going Neoplasia: the second decade.Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer.Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer.Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101)Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells.Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo.HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression Broad targeting of resistance to apoptosis in cancer.Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.Targeting proliferation and survival pathways in head and neck cancer for therapeutic benefit Protection of dietary polyphenols against oral cancer.Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol.Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents.A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer.AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule.Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice.AT-101 inhibits hedgehog pathway activity and cancer growth.Integrative Medicine in Head and Neck Cancer.Autophagy in Cancer Therapy.The Bcl-2/Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma cancer cells.Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer.ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway.

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P2860

(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

http://www.wikidata.org/entity/Q35052194

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2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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(-)-gossypol inhibits growth a ...... quamous cell carcinoma in vivo

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(-)-gossypol inhibits growth a ...... quamous cell carcinoma in vivo

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Bhavna Kumar

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Bradley S Henson

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Carol R Bradford

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Jianyong Chen

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Keith G Wolter

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Kent A Griffith

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Nisha J D'Silva

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Shaomeng Wang

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Steven J Wang

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P2860

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer.

Bcl-2 family proteins as targets for anticancer drug design.

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment.

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Apoptosis induced by anticancer drugs.

Promoting apoptosis as a strategy for cancer drug discovery.

Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells.

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

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163-172

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10.1593/NEO.05691

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3

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8

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Thomas E. Carey

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2006-03-01T00:00:00Z

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7169584

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16611409

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1578526

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