Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20
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P1343
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunitMutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsCarboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitroPathways of DNA double-strand break repair during the mammalian cell cycleExtensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phaseAnalysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.The Ku-dependent non-homologous end-joining pathway contributes to low-dose radiation-stimulated cell survival.Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoiningDNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.TopBP1 activates ATR through ATRIP and a PIKK regulatory domainSingle-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.Activation of ATR and related PIKKsDeletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repairDifferential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.Tip60: connecting chromatin to DNA damage signaling.Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity.The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replicationHomologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells.
P2860
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P2860
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Molecular and biochemical char ...... defective rodent mutant irs-20
@ast
Molecular and biochemical char ...... defective rodent mutant irs-20
@en
type
label
Molecular and biochemical char ...... defective rodent mutant irs-20
@ast
Molecular and biochemical char ...... defective rodent mutant irs-20
@en
prefLabel
Molecular and biochemical char ...... defective rodent mutant irs-20
@ast
Molecular and biochemical char ...... defective rodent mutant irs-20
@en
P2093
P2860
P50
P356
P1476
Molecular and biochemical char ...... defective rodent mutant irs-20
@en
P2093
A G Amatucci
A Priestley
B K Singleton
G E Taccioli
H J Beamish
J S Bedford
M C Muhlmann-Diaz
P2860
P304
P356
10.1093/NAR/26.8.1965
P407
P577
1998-04-01T00:00:00Z