The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines.
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Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosisp14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activityThe Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosisInduction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathwaySmall activating RNA restores the activity of the tumor suppressor HIC-1 on breast cancerLoss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinomaCeramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells.Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis.Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability.Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy.Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway.Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik.Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy.BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes.Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancerAnti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells.Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia.NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinomaStar-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine.Overexpression of HOXB7 protein reduces sensitivity of oral cancer cells to chemo-radiotherapy.Genome-wide study identifies the regulatory gene networks and signaling pathways from chondrocyte and peripheral blood monocyte of Kashin-Beck disease.Therapeutic targeting of C-terminal binding protein in human cancer.Remarkably reduced expression of FoxO3a in metaplastic colorectum, primary colorectal cancer and liver metastasis.
P2860
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P2860
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@ast
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@en
type
label
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@ast
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@en
prefLabel
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@ast
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@en
P2093
P2860
P356
P1433
P1476
The apoptosis promoting Bcl-2 ...... sing breast cancer cell lines.
@en
P2093
Bernd Dörken
Bernhard Gillissen
Isrid Sturm
Peter T Daniel
Silke Radetzki
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205010
P407
P577
2002-01-01T00:00:00Z
P5875
P6179
1038413481