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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

http://www.wikidata.org/entity/Q33235503

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DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1 PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1 DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products Biochemical premotor biomarkers for Parkinson's disease Network analysis reveals common host protein/s modulating pathogenesis of neurotropic viruses Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Cysteine p K a Depression by a Protonated Glutamic Acid in Human DJ-1 † ‡Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1 Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer What is the Clinical Significance of Cerebrospinal Fluid Biomarkers in Parkinson's disease? Is the Significance Diagnostic or Prognostic?Proteomics of protein post-translational modifications implicated in neurodegeneration Mass spectrometry-based methods for identifying oxidized proteins in disease: advances and challenges Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.Products of Cu(II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide.DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene Protection of pancreatic beta-cells from various stress conditions is mediated by DJ-1 Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models.Immunostaining of oxidized DJ-1 in human and mouse brains A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development.Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease.Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis.

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P2860

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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2006 nî lūn-bûn

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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type

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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P1433

Journal of Biological Chemistry

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

@en

P2093

Allan I Levey

http://www.w3.org/2001/XMLSchema#string

David E Bostwick

http://www.w3.org/2001/XMLSchema#string

Howard D Rees

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Joungil Choi

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M Cameron Sullards

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Marla Gearing

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Susan T Weintraub

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P2860

DJ-1 has a role in antioxidative stress to prevent cell death

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Methionine residues as endogenous antioxidants in proteins

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

Proposal for a common nomenclature for sequence ions in mass spectra of peptides

Protein aggregation and neurodegenerative disease

Regulation of cell function by methionine oxidation and reduction

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10816-10824

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scholarly article

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10.1074/JBC.M509079200

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16

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281

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P577

2006-03-03T00:00:00Z

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P698

16517609

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Alzheimer's disease

Parkinson's disease

P932

1850953

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