L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system - Wikidata - wikimedia - TriplyDB

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

http://www.wikidata.org/entity/Q28185988

about

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death DJ-1 has a role in antioxidative stress to prevent cell death RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD Mitochondrial localization of DJ-1 leads to enhanced neuroprotection Genetics of Parkinson disease Evolutionary and functional relationships within the DJ1 superfamily Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Structural effects of Parkinson's disease linked DJ-1 mutations.Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity.DJ-1, PINK1, and their effects on mitochondrial pathways DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development.Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Parkinson's disease: Exit toxins, enter genetics L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments Unravelling the role of defective genes.Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death.Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.The genetics of Parkinson disease.The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

P2860

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P2860

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

http://www.wikidata.org/entity/Q28185988

description

2003 nî lūn-bûn

@nan

2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@ast

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@en

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@nl

type

label

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@ast

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@en

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@nl

prefLabel

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@ast

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@en

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@nl

P1433

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P2860

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P3181

P356

P1433

Journal of Biological Chemistry

P1476

L166P mutant DJ-1, causative f ...... he ubiquitin-proteasome system

@en

P2093

Chris McLendon

http://www.w3.org/2001/XMLSchema#string

Craig Blackstone

http://www.w3.org/2001/XMLSchema#string

David W Miller

http://www.w3.org/2001/XMLSchema#string

Donald M Carter

http://www.w3.org/2001/XMLSchema#string

Gary R Klinefelter

http://www.w3.org/2001/XMLSchema#string

Jayanth Chandran

http://www.w3.org/2001/XMLSchema#string

Julia Stadler

http://www.w3.org/2001/XMLSchema#string

Melisa J Baptista

http://www.w3.org/2001/XMLSchema#string

Peng-Peng Zhu

http://www.w3.org/2001/XMLSchema#string

Rili Ahmad

http://www.w3.org/2001/XMLSchema#string

P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution

The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

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36588-95

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scholarly article

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1692113

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P356

10.1074/JBC.M304272200

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P407

P433

38

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P478

278

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P577

2003-09-19T00:00:00Z

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P698

12851414

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P921

Parkinson's disease

ubiquitin-proteasome system