Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.
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Selective androgen receptor modulators in preclinical and clinical developmentOckham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cellsExactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptorIdentification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.Condition-specific target prediction from motifs and expression.Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMAComparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice.Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptorDevelopment of selective androgen receptor modulators (SARMs).The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: addressing the "core issue" in the design of estrogen receptor ligandsStructural dynamics, intrinsic disorder, and allostery in nuclear receptors as transcription factors.Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.Non-competitive androgen receptor inhibition in vitro and in vivo.Variable steroid receptor responses: Intrinsically disordered AF1 is the key.Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain.Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitroImproving selective androgen receptor modulator discovery and preclinical evaluation.Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.The long and winding road for selective androgen receptor modulators.RhoGDIα downregulates androgen receptor signaling in prostate cancer cells.CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression.PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium.Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor
P2860
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P2860
Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Linking ligand-induced alterat ...... androgen receptor modulators.
@ast
Linking ligand-induced alterat ...... androgen receptor modulators.
@en
type
label
Linking ligand-induced alterat ...... androgen receptor modulators.
@ast
Linking ligand-induced alterat ...... androgen receptor modulators.
@en
prefLabel
Linking ligand-induced alterat ...... androgen receptor modulators.
@ast
Linking ligand-induced alterat ...... androgen receptor modulators.
@en
P2093
P356
P1476
Linking ligand-induced alterat ...... androgen receptor modulators.
@en
P2093
C Edgar Cook
Ching-yi Chang
David Beratan
Dmitri Kazmin
Donald P McDonnell
J D Norris
Russell Wolfinger
Tatiana Prytkova
Tzu-Ming Chu
P304
P356
10.1210/ME.2005-0309
P577
2006-03-30T00:00:00Z