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Non-competitive androgen receptor inhibition in vitro and in vivo.

Non-competitive androgen receptor inhibition in vitro and in vivo.

http://www.wikidata.org/entity/Q37182710

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Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers Targeting the androgen receptor with steroid conjugates Wnt/β-catenin signalling in prostate cancer Differential effects of genistein on prostate cancer cells depend on mutational status of the androgen receptor An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.Intrinsic disorder in the androgen receptor: identification, characterisation and drugability.Advances in small molecule inhibitors of androgen receptor for the treatment of advanced prostate cancer.Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin Molecular pathways and targets in prostate cancer A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.Recent advances in allosteric androgen receptor inhibitors for the potential treatment of castration-resistant prostate cancer.Small molecule inhibitors as probes for estrogen and androgen receptor action Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery.Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation.Pyrvinium targets autophagy addiction to promote cancer cell death.Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Inhibition of hedgehog and androgen receptor signaling pathways produced synergistic suppression of castration-resistant prostate cancer progression.AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization.MUC1 oncoprotein is a druggable target in human prostate cancer cells.Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges.Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium.Vitamin K epoxide reductase regulation of androgen receptor activity.Novel, potent anti-androgens of therapeutic potential: recent advances and promising developments.Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Improving selective androgen receptor modulator discovery and preclinical evaluation.Low Testosterone Alters the Activity of Mouse Prostate Stem Cells.The novel role of pyrvinium in cancer therapy.Synthesis and evaluation of novel thiazole-based derivatives as selective inhibitors of DNA-binding domain of the androgen receptor.Prostate Cancer Stem Cells and Nanotechnology: A Focus on Wnt Signaling.Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate.Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells.

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Non-competitive androgen receptor inhibition in vitro and in vivo.

http://www.wikidata.org/entity/Q37182710

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 April 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Non-competitive androgen receptor inhibition in vitro and in vivo.

@en

Non-competitive androgen receptor inhibition in vitro and in vivo.

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type

label

Non-competitive androgen receptor inhibition in vitro and in vivo.

@en

Non-competitive androgen receptor inhibition in vitro and in vivo.

@nl

prefLabel

Non-competitive androgen receptor inhibition in vitro and in vivo.

@en

Non-competitive androgen receptor inhibition in vitro and in vivo.

@nl

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PNAS.0807282106

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Proceedings of the National Academy of Sciences of the United States of America

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Non-competitive androgen receptor inhibition in vitro and in vivo

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P2093

Byron Hann

http://www.w3.org/2001/XMLSchema#string

Clementine Feau

http://www.w3.org/2001/XMLSchema#string

Eric C Bolton

http://www.w3.org/2001/XMLSchema#string

Marc I Diamond

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Yong Huang

http://www.w3.org/2001/XMLSchema#string

P2860

The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions

The program of androgen-responsive genes in neoplastic prostate epithelium.

Molecular determinants of resistance to antiandrogen therapy

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.

Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

Molecular biology of the androgen receptor.

Cell- and gene-specific regulation of primary target genes by the androgen receptor.

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.

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10.1073/PNAS.0807282106

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