Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
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High affinity soluble ILT2 receptor: a potent inhibitor of CD8(+) T cell activationGenetic engineering of T cells for adoptive immunotherapyIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡T-cell Receptor Specificity Maintained by Altered ThermodynamicsIncreased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeT-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex InteractionsComputational Design of the Affinity and Specificity of a Therapeutic T Cell ReceptorDynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one.Predicting peptide binding affinities to MHC molecules using a modified semi-empirical scoring function.Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire.Monoclonal TCR-redirected tumor cell killing.Specific increase in potency via structure-based design of a TCR.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and functionDirected evolution of a fluorogen-activating single chain antibody for function and enhanced brightness in the cytoplasmEngineering improved T cell receptors using an alanine-scan guided T cell display selection systemIdentification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Specific roles of each TCR hemichain in generating functional chain-centric TCR.Soluble T-cell receptors produced in human cells for targeted delivery.T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope RecognitionInterplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.T-cell receptor gene therapy of established tumors in a murine melanoma modelDirect molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.SHP-1 phosphatase activity counteracts increased T cell receptor affinity.Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Structure-Based, Rational Design of T Cell Receptors.Enhanced T cell receptor gene therapy for cancer.Challenges in T cell receptor gene therapy.Molecular insights for optimizing T cell receptor specificity against cancer.Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions.Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragmentsThe complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function.Changing the peptide specificity of a human T-cell receptor by directed evolution.
P2860
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P2860
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Directed evolution of human T ...... ing apparent cross-reactivity.
@ast
Directed evolution of human T ...... ing apparent cross-reactivity.
@en
type
label
Directed evolution of human T ...... ing apparent cross-reactivity.
@ast
Directed evolution of human T ...... ing apparent cross-reactivity.
@en
prefLabel
Directed evolution of human T ...... ing apparent cross-reactivity.
@ast
Directed evolution of human T ...... ing apparent cross-reactivity.
@en
P2093
P2860
P356
P1433
P1476
Directed evolution of human T ...... ing apparent cross-reactivity.
@en
P2093
Bent K Jakobsen
Brian Cameron
Emma Baston
Jonathan Boulter
Malkit Sami
Pierre J Rizkallah
Ruth Moysey
Steven M Dunn
Tara Mahon
P2860
P304
P356
10.1110/PS.051936406
P577
2006-04-01T00:00:00Z