Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. - Wikidata - wikimedia - TriplyDB

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

http://www.wikidata.org/entity/Q33244294

about

Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism Small molecule tools for functional interrogation of protein tyrosine phosphatases Natural killer cell signal integration balances synapse symmetry and migration Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo Small-molecule inhibitors of the Rce1p CaaX protease Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4 Lymphocyte cell-cycle inhibition by HLA-G is mediated by phosphatase SHP-2 and acts on the mTOR pathway Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events.The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters.Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.Targeting PTPs with small molecule inhibitors in cancer treatment Phosphatase inhibitors with anti-angiogenic effect in vitro SHP-2 is required for the maintenance of cardiac progenitors.Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium.Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC).CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility.Critical role of Shp2 in tumor growth involving regulation of c-Myc Targeting protein tyrosine phosphatases for anticancer drug discovery.A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.Molecular targets for the treatment of juvenile myelomonocytic leukemia.The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.N-Acetyl-seryl-aspartyl-lysyl-proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts.Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.

P2860

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P2860

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

http://www.wikidata.org/entity/Q33244294

description

2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@ast

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@en

type

label

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@ast

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@en

prefLabel

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@ast

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@en

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Molecular Pharmacology

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Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

@en

P2093

Harshani R Lawrence

http://www.w3.org/2001/XMLSchema#string

Jie Wu

http://www.w3.org/2001/XMLSchema#string

Liwei Chen

http://www.w3.org/2001/XMLSchema#string

M L Richard Yip

http://www.w3.org/2001/XMLSchema#string

Nicholas J Lawrence

http://www.w3.org/2001/XMLSchema#string

Said M Sebti

http://www.w3.org/2001/XMLSchema#string

Shen-Shu Sung

http://www.w3.org/2001/XMLSchema#string

Wayne C Guida

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Yuan Ren

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562-570

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scholarly article

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10.1124/MOL.106.025536

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2

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70

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2006-05-22T00:00:00Z

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7064880

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16717135

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