Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. - Wikidata - wikimedia - TriplyDB

Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.

Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.

http://www.wikidata.org/entity/Q33251085

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The hedgehog pathway in triple-negative breast cancer Esophageal cancer stem cells and implications for future therapeutics Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis The Role of Hedgehog Signaling in Tumor Induced Bone Disease Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer A novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathway Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway.Pathway analysis using random forests with bivariate node-split for survival outcomes Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer.Microgenomics of ameloblastoma Hedgehog signaling in the normal and neoplastic mammary gland.Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer.Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland.Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 breast cancer cells--interaction of hedgehog-gli and estrogen receptor signaling pathways.Shared signaling pathways in normal and breast cancer stem cells.Inhibition of hedgehog signaling reduces the side population in human malignant mesothelioma cell lines.Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.GLI1 Transcription Factor Affects Tumor Aggressiveness in Patients With Papillary Thyroid Cancers.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Breast cancer progression: controversies and consensus in the molecular mechanisms of metastasis and EMT A method for identifying discriminative isoform-specific peptides for clinical proteomics application.Small molecule Hedgehog pathway antagonists.Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells.Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients.Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms.Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells.Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition Implications of hedgehog signaling antagonists for cancer therapy.Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.

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P2860

Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.

http://www.wikidata.org/entity/Q33251085

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2006 nî lūn-bûn

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Hedgehog signaling and respons ...... nign breast and breast cancer.

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Andra R Frost

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Andrea Sadlonova

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P2860

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture

Activation of the hedgehog pathway in advanced prostate cancer

Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy

Coincident PTCH and BRCA1 germline mutations in a patient with nevoid basal cell carcinoma syndrome and familial breast cancer

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells

Sonic hedgehog expression and role in healing corneal epithelium

The Gli2 transcription factor is required for normal mouse mammary gland development

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