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Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinasesTransport mechanisms and their pathology-induced regulation govern tyrosine kinase inhibitor delivery in rheumatoid arthritisImportance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts.Membrane transporters as mediators of Cisplatin effects and side effects.Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis.Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functionsElemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin.Regulation of organic cation transport.A phosphotyrosine switch regulates organic cation transporters.Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2Saving ears and kidneys from cisplatin.Membrane transporters as mediators of cisplatin side-effects.Role of transporters in the distribution of platinum-based drugs.Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation.The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3.Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.Kidney transplantation down-regulates expression of organic cation transporters, which translocate β-blockers and fluoroquinolones.New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2.Calmodulin-associated post-translational regulation of rat organic cation transporter 2 in the kidney is gender dependent.Regulation of the human organic cation transporter hOCT1.The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP.Specific binding of cardiac glycoside drugs and endogenous digitalis-like substances to particulate membrane fractions from human placenta.The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.Lung tissue binding of iodobenzyl-propanediamine: involvement of beta-adrenergic receptors.The "fixed" charge of glomerular capillary wall as determinant of permselectivity.Cystatin C in a rat model of end-stage renal failure.Dynamic alterations of glomerular charge density in fixed rat kidneys suggest involvement of endothelial cell coat.Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule.Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.In reference to Immunohistochemical localization of OCT2 in the cochlea of various species.Characterization of regulatory mechanisms and states of human organic cation transporter 2.Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.Evaluation of pharmacogenetic markers to predict the risk of Cisplatin-induced ototoxicity.Rho GAP myosin IXa is a regulator of kidney tubule function.
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P50
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հետազոտող
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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Giuliano Ciarimboli
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P214
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