cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
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Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide BindingCrystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain CommunicationStructural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG IDevelopment of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug targetCrystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egressThe malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony.Native MS: an 'ESI' way to support structure- and fragment-based drug discovery.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pocketsPrevention of PKG1α oxidation augments cardioprotection in the stressed heart.Direct binding and regulation of RhoA protein by cyclic GMP-dependent protein kinase IαHydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system.Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability.Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.Stability and shape of hepatitis B virus capsids in vacuo.Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinaseIon mobility mass spectrometry of proteins and protein assemblies.Capturing protein structural kinetics by mass spectrometry.cGMP becomes a drug target.Integration of phosphoproteomic, chemical, and biological strategies for the functional analysis of targeted protein phosphorylation.Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials.West Nile virus methyltransferase domain interacts with protein kinase G.Mass spectrometry locates local and allosteric conformational changes that occur on cofactor bindingPhosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells.Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions.Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: the effect of ligand binding on conformational stability.Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Iα.Identification of Dual Mechanisms Mediating 5-hydroxytryptamine Receptor 1F Induced Mitochondrial Biogenesis.An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric, autoinhibited, and provides a model for activation.Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46.
P2860
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P2860
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@ast
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@en
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@nl
type
label
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@ast
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@en
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@nl
prefLabel
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@ast
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@en
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain.
@nl
P2093
P1476
cGMP-binding prepares PKG for substrate binding by disclosing the C-terminal domain
@en
P2093
Arjen Scholten
Cees Versluis
Gennaro Esposito
Hortense Mazon
Robert van den Heuvel
Vera Alverdi
Wieger Hemrika
P304
P356
10.1016/J.JMB.2007.11.053
P407
P577
2007-11-22T00:00:00Z