Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction
about
Synthetic lethal screens as a means to understand and treat MYC-driven cancersThe paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesOptimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designingCharacterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor DesignFluorescence polarization/anisotropy in diagnostics and imagingHigh-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activityA high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.A robotic platform for quantitative high-throughput screeningHigh-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship studyA quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agentsSmall molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesExploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.Fluorescence polarization assays in small molecule screening.Irreversible binding of an anticancer compound (BI-94) to plasma proteins.Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option.A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductaseProtein-protein interactions as therapeutic targets in neuropsychopharmacology.Targeting homologous recombination-mediated DNA repair in cancer.Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.
P2860
Q27006010-4979E4D2-2008-4575-A17C-B07BCB0F61D9Q27677282-D1119755-88FE-49A1-BE45-C7C33DFDF8E2Q28475117-0E9C8A0B-B22F-4BB2-8B0E-2A2A79767D08Q28553736-E1823993-9EA5-4C17-8788-0EEB55BFFD03Q28752224-E08400A5-5063-4B68-B77D-17578C3DDBD8Q30009835-4D1397DE-550F-4818-BDC7-280E91DD64C8Q33341121-7AD4BF04-3A51-4327-A3CE-E6DFB5A86D09Q33387376-E24C1843-0F10-42C2-9E37-450539B059C5Q33762830-D43AC9DF-E6B8-4CCC-B0A7-67F2F71FD3D8Q33837666-F2C6867D-E601-4874-97D5-F1C0C20A913CQ33868762-FE7DC416-00B0-4539-BC83-DAAC687097D5Q34252163-B218D39F-E335-49C9-A909-05D97412C180Q34554617-6CD6952A-D06C-4598-80AB-3DA8FE5DD412Q35224775-174F914D-273C-4CDF-9E81-051C803833CCQ35445886-4D0F436A-67B1-4D53-B018-168AFFDB2BB1Q35750597-FB07DB09-94A8-4247-8B9A-BC9908907450Q36005906-E8BF8F20-ECAD-4566-93F5-1C74FD41EDFFQ36110001-B8C2FEA2-9463-4692-B23F-11D02CEDD3BBQ37158887-A6BAC88F-9725-4A9E-8005-9AAA121FFFEAQ37349672-EF963F33-2A35-49F4-805E-EA78C0954060Q38184667-A74896FC-46A5-4C25-91C8-2342D3C399EFQ39386461-94D257E9-2B7E-45AE-9D47-AD4AEF2A3EA6Q42761664-EBF51F76-CBBA-4D1F-ADCA-33B74DA5916A
P2860
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@ast
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@en
Dual-fluorophore quantitative ...... CT-phosphoprotein interaction.
@nl
type
label
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@ast
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@en
Dual-fluorophore quantitative ...... CT-phosphoprotein interaction.
@nl
prefLabel
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@ast
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@en
Dual-fluorophore quantitative ...... CT-phosphoprotein interaction.
@nl
P2093
P2860
P50
P356
P1476
Dual-fluorophore quantitative ...... RCT-phosphoprotein interaction
@en
P2093
Carleen Klumpp
G L Lokesh
James Inglese
Sam Michael
P2860
P356
10.1016/J.AB.2007.11.039
P407
P577
2007-12-05T00:00:00Z