HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.
about
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin ZMolecular targets for flavivirus drug discoveryThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicaseIdentification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput ScreenDiscovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput DockingProgress on the development of therapeutics against West Nile virusStructure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinaseNMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 ProteaseEffects of detergents on the West Nile virus protease activityFocus on flaviviruses: current and future drug targetsSerotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus FamilyAllosteric Inhibition of the NS2B-NS3 Protease from Dengue VirusProbing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinaseEnzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substratesCharacterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists.Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 2-{6-[2-(5-phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold.Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L.Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.Automated image-based phenotypic analysis in zebrafish embryos.Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Discovery, synthesis, and in vitro evaluation of West Nile virus protease inhibitors based on the 9,10-dihydro-3H,4aH-1,3,9,10a-tetraazaphenanthren-4-one scaffold.Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.The flavivirus protease as a target for drug discovery.Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 1,3,4,5-tetrasubstituted 1H-pyrrol-2(5H)-one scaffold.Using Caenorhabditis elegans to study serpinopathies.Identification of covalent active site inhibitors of dengue virus protease.Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity.Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents.West Nile virus drug discovery.An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.Structure-guided fragment-based in silico drug design of dengue protease inhibitors.
P2860
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P2860
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
HTS identifies novel and speci ...... proteinase of West Nile virus.
@ast
HTS identifies novel and speci ...... proteinase of West Nile virus.
@en
HTS identifies novel and speci ...... proteinase of West Nile virus.
@nl
type
label
HTS identifies novel and speci ...... proteinase of West Nile virus.
@ast
HTS identifies novel and speci ...... proteinase of West Nile virus.
@en
HTS identifies novel and speci ...... proteinase of West Nile virus.
@nl
prefLabel
HTS identifies novel and speci ...... proteinase of West Nile virus.
@ast
HTS identifies novel and speci ...... proteinase of West Nile virus.
@en
HTS identifies novel and speci ...... proteinase of West Nile virus.
@nl
P2093
P50
P356
P1476
HTS identifies novel and speci ...... proteinase of West Nile virus.
@en
P2093
Boris I Ratnikov
Jeffrey W Smith
Jennifer Phillips
Michael C Myers
Nicholas D P Cosford
Russell Dahl
Sergey A Shiryaev
Sunita Shinde
P304
P356
10.1089/ADT.2007.101
P577
2007-12-01T00:00:00Z