Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.
about
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin ZEvaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cellsAn ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegansHCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell linesDevelopment and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.Challenges in secondary analysis of high throughput screening dataImplementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches.2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship studyInhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.Using Caenorhabditis elegans to study serpinopathies.Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.New Approaches to Difficult Drug Targets: The Phosphatase Story
P2860
Q21562132-24BC75E0-39E4-40C9-9830-C401A25E3D8CQ28391247-B5EB325E-29D9-4F7A-BECA-2FDB37FAB609Q28487176-387AE33E-E48B-4E6E-93D3-006A395C6940Q30278790-A910C122-28A6-40C9-AC30-A8CCC422B983Q30416877-4EF42F9A-8356-40E4-9C38-58A1CAAAA1C3Q30705788-4DDE0E73-34B7-40F8-9933-D7F7D5C3AFD7Q30985752-7B09B17B-BF33-4168-9ADE-C73881E83431Q33523595-ACAFF43F-7A07-4025-84C5-85217F666AC2Q33642043-5BA371DD-17D6-4ED7-B5F6-06524D238C76Q33772474-8E5759F9-A428-4066-BFB3-ED6C9293A178Q33779423-56EAD652-8395-4B0D-B372-09BB95029C47Q33837666-EB4FE968-F7B6-4DD3-BD59-EDA28ED49E98Q34005613-13969B01-3EB9-43B3-B279-1E75982C2862Q34097208-0CEA4B17-968E-4CB9-AFEF-D860B9CCD298Q35218752-86074023-B2C0-45DD-933B-49CEB6938425Q35406908-90F1D70A-14E4-411D-828C-C1F23886654FQ37809299-D3069AD7-4E70-4914-9629-4A5556016BF8Q38268221-CB90F316-B41E-470D-8B8C-8B0EE06BEC4BQ38747617-CF6BA9FE-8CC5-4EC6-94CC-810A0D35BB21Q39386461-EDD1B9B9-4ADA-47E4-882B-8DA43FDCE348Q56513340-814607A2-5654-4761-9438-08FFE58649A6
P2860
Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@ast
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@en
type
label
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@ast
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@en
prefLabel
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@ast
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@en
P2093
P2860
P50
P356
P1476
Cdc25B dual-specificity phosph ...... n of the NIH compound library.
@en
P2093
Caleb A Foster
Kay M Brummond
Marni Brisson Tierno
Sunita N Shinde
William D Paquette
P2860
P304
P356
10.1089/ADT.2008.186
P577
2009-06-01T00:00:00Z