Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
about
The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosisRedox-directed cancer therapeutics: molecular mechanisms and opportunitiesIdentifying druggable disease-modifying gene productsMechanisms of ferroptosisFerroptosis, a new form of cell death, and its relationships with tumourous diseasesNon-Canonical Cell Death Induced by p53HSPB1 as a novel regulator of ferroptotic cancer cell deathIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesActivation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cellsErastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer CellsAblation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells.Combination chemical geneticsMethodological approaches in application of synthetic lethality screening towards anticancer therapyEmerging roles for lipids in non-apoptotic cell deathRegulation of ferroptotic cancer cell death by GPX4Oxidized arachidonic and adrenic PEs navigate cells to ferroptosisFive-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells.Ferroptosis: an iron-dependent form of nonapoptotic cell deathLoss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivationFerroptosis: Death by Lipid Peroxidation.Ferroptosis: process and function.Development of small-molecule probes that selectively kill cells induced to express mutant RASVDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.VDAC3 and Mps1 negatively regulate ciliogenesis.Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease modelsA Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stressModulatory profiling identifies mechanisms of small molecule-induced cell death.Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms.Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High PotencyUsing Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis.The neglected significance of "antioxidative stress".Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinomaMultivalent Small-Molecule Pan-RAS Inhibitors.Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.VDAC1: from structure to cancer therapy.Role of labile iron in the toxicity of pharmacological ascorbate
P2860
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P2860
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@ast
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@en
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@nl
type
label
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@ast
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@en
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@nl
prefLabel
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@ast
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@en
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@nl
P2860
P1476
Synthetic lethal screening ide ...... ic-RAS-harboring cancer cells.
@en
P2093
Brent R Stockwell
Wan Seok Yang
P2860
P304
P356
10.1016/J.CHEMBIOL.2008.02.010
P577
2008-03-01T00:00:00Z