Modulatory profiling identifies mechanisms of small molecule-induced cell death. - Wikidata - wikimedia - TriplyDB

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

http://www.wikidata.org/entity/Q35239947

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Mechanisms of ferroptosis Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy Ferroptosis, a new form of cell death, and its relationships with tumourous diseases Differential mitochondrial toxicity screening and multi-parametric data analysis Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways Transcriptional data: a new gateway to drug repositioning?Predicting cancer drug mechanisms of action using molecular network signatures.Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis Regulation of ferroptotic cancer cell death by GPX4 Ferroptosis: an iron-dependent form of nonapoptotic cell death [Ferroptosis, a new form of cell death relevant to the medical treatment of cancer].Ferroptosis: Death by Lipid Peroxidation.Unraveling the mechanism of cell death induced by chemical fibrils.Chemical biology applied to the study of bacterial pathogens.Target identification and mechanism of action in chemical biology and drug discovery.Anti-breast Cancer Agents Derived from Plants.Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency Elucidating Compound Mechanism of Action by Network Perturbation Analysis.Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis.Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.Improving compound-protein interaction prediction by building up highly credible negative samples.Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization.Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.Understanding resistance to combination chemotherapy.Drug repositioning by applying 'expression profiles' generated by integrating chemical structure similarity and gene semantic similarity.PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens.Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targets.Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib.Ferroptosis: bug or feature?The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo.Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis NPC-26 kills human colorectal cancer cells via activating AMPK signaling.Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

http://www.wikidata.org/entity/Q35239947

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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Modulatory profiling identifies mechanisms of small molecule-induced cell death.

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PNAS.1106149108

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Proceedings of the National Academy of Sciences of the United States of America

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Modulatory profiling identifies mechanisms of small molecule-induced cell death

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Brent R Stockwell

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Dana Pe'er

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Fatima Shaik

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J Chloe Bulinski

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Matthew E Welsch

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics

Variations in DNA elucidate molecular networks that cause disease

Predicting new molecular targets for known drugs

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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108

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Kenichi Shimada

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2011-09-06T00:00:00Z

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51624056

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