Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding.
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Landmarks in insulin researchAlanine scanning of a putative receptor binding surface of insulin-like growth factor-IMolecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading EnzymeStructural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary ConservationInsulin analog with additional disulfide bond has increased stability and preserved activityNovel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin DimerizationMolecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analoguesEngineering of insulin receptor isoform-selective insulin analoguesContribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability.Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its BindingThe insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.Tissue barriers and novel approaches to achieve hepatoselectivity of subcutaneously-injected insulin therapeutics.Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30: a monomeric insulin variant.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.Receptor-isoform-selective insulin analogues give tissue-preferential effects.In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin).All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.Identification of anchor points for chemical modification of a small cysteine-rich protein by using a cysteine scan.
P2860
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P2860
Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Importance of the solvent-expo ...... ha-helix for receptor binding.
@ast
Importance of the solvent-expo ...... ha-helix for receptor binding.
@en
Importance of the solvent-expo ...... ha-helix for receptor binding.
@nl
type
label
Importance of the solvent-expo ...... ha-helix for receptor binding.
@ast
Importance of the solvent-expo ...... ha-helix for receptor binding.
@en
Importance of the solvent-expo ...... ha-helix for receptor binding.
@nl
prefLabel
Importance of the solvent-expo ...... ha-helix for receptor binding.
@ast
Importance of the solvent-expo ...... ha-helix for receptor binding.
@en
Importance of the solvent-expo ...... ha-helix for receptor binding.
@nl
P2093
P356
P1433
P1476
Importance of the solvent-expo ...... ha-helix for receptor binding.
@en
P2093
Anders R Sørensen
Erica Nishimura
Ingrid Pettersson
Thomas Kjeldsen
Tine Glendorf
P304
P356
10.1021/BI800054Z
P407
P577
2008-04-01T00:00:00Z