Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.
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Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particlesHIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexesNegative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivitySubunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinerySERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefStructure--function relationships in HIV-1 Nef.Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsHuman immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells.p56Lck anchors CD4 to distinct microdomains on microvilli.Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexesHIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsHIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanismsThe human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factorsTargeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4HIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchThe macrophage: a therapeutic target in HIV-1 infectionThe evolution and genetics of virus host shiftsHIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors.How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.Lentivirus Nef specifically activates Pak2.Betaretroviral envelope subunits are noncovalently associated and restricted to the mammalian classThe HIV-1 Nef protein as a target for antiretroviral therapy.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity.Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion releaseModulation of HIV-1-host interaction: role of the Vpu accessory proteinNef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane.HIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cellsHIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefHuman immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinaseExogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis.Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus.Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals.Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivityCD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivoHuman immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinNef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.
P2860
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P2860
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@ast
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@en
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@nl
type
label
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@ast
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@en
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@nl
prefLabel
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@ast
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@en
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@nl
P2093
P1433
P1476
Cell-surface expression of CD4 ...... f- and Vpu-inhibitable manner.
@en
P2093
P304
P356
10.1016/S0960-9822(99)80284-X
P407
P577
1999-06-01T00:00:00Z