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Down-regulation of CTLA-4 by HIV-1 Nef proteinHIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxisSystematic identification of regulatory proteins critical for T-cell activationA hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix."UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionGenetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolatesReconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylationDynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressorsTrans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.Structural constraints on human immunodeficiency virus type 1 Nef function.Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 NefPAK1 as a therapeutic target.In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss.CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variableNef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.Viral modulation of T-cell receptor signalingHIV-1 Nef: at the crossroadsSuppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration.Mechanisms of HIV-1 Nef function and intracellular signaling.Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins.Nef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice.Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor NefHuman immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid raftsPAK in pathogen-host interactions.Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.Nef mediated activation of the T-cell receptorHIV Nef increases T cell ERK MAP kinase activity.
P2860
Q21090808-FAB91E18-F4F6-4D34-9D82-5AA066001DFFQ21146434-3A0EC330-0D3D-4ADB-9085-0E7F9EF28A95Q21245890-FECD2C31-0BD7-4E7A-A8AC-82AD5E823900Q28768294-C5D61320-62E4-4BA4-A2F1-9614F8C7CB50Q30009533-30F2F79A-EC6C-42B9-8F73-B7493281547BQ30010085-FBD12A4B-6998-4053-BA72-00230302686EQ33229419-494FB0D2-6425-4ABA-8C9E-DD309C808DAFQ33837307-7B05ACF5-2712-45B2-8BEB-F9D845CD46D3Q34045736-66213AA8-FA31-4774-9C73-E2C19AF0DE02Q34142952-5354314A-B1BB-4F2A-B5E9-AB486D7BACC9Q34302168-8CD4D7B1-35F4-459F-A9AF-29E5C003FA43Q34340441-FFB461C7-DC0B-4798-A39E-0274B2EF5DF5Q34403732-1FF6EFFC-8CD7-4588-8987-553ACCF729FFQ34518000-00DCE331-B08C-4160-8C70-B7337C8796EFQ35024084-32195391-06A4-4472-969C-5E36F8F4725BQ35108164-0510D661-F6D1-4938-BF91-A91BE20C2A49Q35848314-57733CBA-ADD1-4CA9-9C2A-4C8EE279EBE8Q36015423-9C6F4FE6-BE8F-4488-ACAD-998B58326A80Q36112824-F24973E3-61C6-4830-AED0-C65A75F4CB0DQ36540182-2FA5F7CE-DF3F-4CB2-B6D8-4877EA15D91CQ36926697-28B9E5C0-7892-4610-B8D1-AA7FEFE65B80Q37101393-8C0939B9-4DE5-49CF-8C98-EE386008600EQ37183848-D9089A50-3EBD-41D8-97F5-93B2E629D87CQ37743507-7DC1BF35-3FFE-4B8F-AE50-853AA6102726Q38260894-33F6CFE9-B33A-47A8-AF44-38EDB9771D9CQ38316915-031A0C44-BE7E-4C98-96BA-D812E2CDE4F2Q38356666-C06E17D0-38CA-4FD7-A03B-8E7C95BD38F0Q38657287-9D6DC298-C331-4B5F-A634-FC99EA2B9168Q39358737-4F3A3B37-3889-4DAB-9ACA-CC11DDD1AB7DQ39741159-F18B9A84-7D74-434F-890A-A0592C85ACF4Q40078268-97633F1D-BFAB-42D8-84E5-1A7C2121F7C8Q40273924-78A50D0A-C0A5-4FB1-A9D8-348B1E96905EQ40471343-61381E14-AC7C-4FE3-843C-D3A42353D8C8Q40572781-99BA106E-E3BE-485B-955E-21E1A856F657Q41592775-9842F29A-EFEB-4F12-BB69-138B5CEF410AQ42157622-25946B71-2321-455F-805E-B909F195BD15Q47273958-8530D4FE-AC92-42CA-B94A-4DCB549314AEQ50289425-AD111248-72BF-45D1-A6D3-B64DA63CF3FDQ51961814-7D17BDA8-7A66-4D8D-BF87-A574A9D6FE23
P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Lentivirus Nef specifically activates Pak2
@nl
Lentivirus Nef specifically activates Pak2.
@ast
Lentivirus Nef specifically activates Pak2.
@en
type
label
Lentivirus Nef specifically activates Pak2
@nl
Lentivirus Nef specifically activates Pak2.
@ast
Lentivirus Nef specifically activates Pak2.
@en
prefLabel
Lentivirus Nef specifically activates Pak2
@nl
Lentivirus Nef specifically activates Pak2.
@ast
Lentivirus Nef specifically activates Pak2.
@en
P2093
P2860
P1433
P1476
Lentivirus Nef specifically activates Pak2.
@en
P2093
B L Fredericksen
J L Blakemore
J L Foster
J V Garcia
R P Molina
P2860
P304
11081-11087
P356
10.1128/JVI.74.23.11081-11087.2000
P577
2000-12-01T00:00:00Z