Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome.
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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndromeStructure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.Structural basis for engagement by complement factor H of C3b on a self surfaceDual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complementThe central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP moduleGenetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcomeProperdin: a tightly regulated critical inflammatory modulatorComplement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from ComplementThe development of atypical hemolytic uremic syndrome depends on complement C5Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structureThe binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countriesMutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.Atypical haemolytic uraemic syndrome and mutations in complement regulator genes.Pathogenesis and prognosis of thrombotic microangiopathy.The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.Complement control protein factor H: the good, the bad, and the inadequate.New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseasesMicrobes bind complement inhibitor factor H via a common siteFusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeuticThe relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococciFactor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes.Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.Essential role of surface-bound complement factor H in controlling immune complex-induced arthritisTranslational mini-review series on complement factor H: structural and functional correlations for factor H.Polyanion-induced self-association of complement factor H.The C-terminus of complement factor H is essential for host cell protection.Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.Complement in removal of the dead - balancing inflammation.Complementopathies.Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization.Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation.Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis.
P2860
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P2860
Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@ast
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@en
type
label
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@ast
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@en
prefLabel
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@ast
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@en
P1476
Cutting edge: localization of ...... for hemolytic uremic syndrome.
@en
P2093
Michael K Pangburn
P304
P356
10.4049/JIMMUNOL.169.9.4702
P407
P577
2002-11-01T00:00:00Z